Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus
نویسندگان
چکیده
منابع مشابه
IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.
Intracellular proteolysis of ingested blood proteins is a crucial physiological process in ticks. In our model tick, Ixodes ricinus, cathepsin L (IrCL1) is part of a gut-associated multi-peptidase complex; its endopeptidase activity is important in the initial phase of haemoglobinolysis. We present the functional and biochemical characterisation of this enzyme. We show, by RNA interference (RNA...
متن کاملIrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
Ticks are ectoparasitic blood-feeders and important vectors for pathogens including arboviruses, rickettsiae, spirochetes and protozoa. As obligate blood-feeders, one possible strategy to retard disease transmission is disruption of the parasite's ability to digest host proteins. However, the constituent peptidases in the parasite gut and their potential interplay in the digestion of the blood ...
متن کاملIsolation of Ixodes ricinus salivary gland mRNA encoding factors induced during blood feeding.
In tick salivary glands, genes induced during blood feeding result in the expression of new proteins secreted into tick saliva. These proteins are potentially involved in modulation of vertebrate host immune and hemostatic responses. In this study, subtractive and full-length cDNA libraries were constructed by use of mRNA extracted from salivary glands of unfed and 5-day engorged Ixodes ricinus...
متن کاملDifferential expression of tick Ixodes ricinus genes induced by blood feeding or infection: genetic analysis of ML domain containing proteins
Blood intake causes significant changes in ticks, triggering vital physiological processes including differential gene expression. A gene encoding Ixodes ricinus ML-domain containing protein (IrML) is one of the set of the genes that are strongly induced by blood meals. IrML belongs to the ML protein family that commonly occurs in diverse organisms and is involved in lipid binding and transport...
متن کاملIxodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding
Ixodes scapularis is the most medically important tick species and transmits five of the 14 reportable human tick borne disease (TBD) agents in the USA. This study describes LC-MS/MS identification of 582 tick- and 83 rabbit proteins in saliva of I. scapularis ticks that fed for 24, 48, 72, 96, and 120 h, as well as engorged but not detached (BD), and spontaneously detached (SD). The 582 tick p...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2010
ISSN: 1756-3305
DOI: 10.1186/1756-3305-3-119